하악 상행지에 발생한 중심성 선암종의 증례보고
A Case Report of Central Adenocarcinoma of Mandible Ascending Ramus
김형근, 이충상, 양동현, 김형준, 정호걸, 육종인, 김현실,
소속 상세정보
김형근 ( Kim Hyoung-Keun ) - 연세대학교 치과대학 구강악안면외과학교실
이충상 ( Lee Choong-Sang ) - 연세대학교 치과대학 구강악안면외과학교실
양동현 ( Yang Dong-Hyun ) - 연세대학교 치과대학 구강병리학교실
김형준 ( Kim Hyung-Jun ) - 연세대학교 치과대학 구강악안면외과학교실
정호걸 ( Jeong Ho-Gul ) - 연세대학교 치과대학 구강악안면방사선학교실
육종인 ( Yook Jong-In ) - 연세대학교 치과대학 구강병리학교실
김현실 ( Kim Hyun-Sil ) - 연세대학교 치과대학 구강종양연구소
KMID : 0829220110350050285
Abstract
The osteoblastic activity of carcinoma is restricted in osteoblastic metastasis, common in the patients with prostate cancer, whereas its mechanism and the factors involved are unknown. Here, we present a case of central adenocarcinoma showing the osteoblastic activity in the mandible of the 80-year-old Korean male who had suffered from the paresthesia of lower lip during four mouths. Clinically the overlying oral epithelium was intact, but the radiologic images revealed the ill-defined radiolucent intraosseous lesions in left ascending ramus. Microscopically, the mandibular lesion was composed with carcinoma of ductal or glandular differentiation but lack typical features of any epithelial salivary gland malignancies. Intriguingly abundant new bone formation was found in the stroma, but the tumor cells expressed no reactivity for prostate-specific antigen(PSA). The patient had low ionized calcium level, normal serum alkaline phosphatase and PSA level. Positron emission tomography-computed tomopraphy scan revealed the benign prostatic hyperplasia, but failed to trace the primary site of tumor other than mandible. Therefore, pathologically diagnosis for the lesion was informed as adenocarcinoma, not otherwise specified(NOS). Because occult primary tumor associated with osteoblastic metastasis cannot be completely ruled out, periodic and careful check-ups for the patient should be performed.
키워드
Adenocarcinoma; Central; Not otherwise specified(NOS); Occult primary tumor; Osteoblastic metastasis
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